![]() ![]() However, if NIMH prematurely establishes for a battery of affective, behavioral, and cognitive tasks for use in RDoC research, it runs the risk of hampering future methodological innovation and revisions to the RDoC constructs, which would have deleterious effects on the long-term development of RDoC. To generate a systematic RDoC database for this purpose, it is important to develop a set of paradigms and measures that are generally accepted by the field and which can facilitate comparisons across studies and sharing of data. The long- term goal is to develop a scientific base that can inform future neuroscience-based diagnostic systems for mental illnesses. RDoC aims to support research that considers mental illnesses in terms of fundamental behavioral-neural systems (e.g., fear or working memory) rather than traditional diagnostic categories. The RDoC matrix provides one framework for organizing NIMH research efforts, freeing scientists from traditional categories that are often heterogeneous and overlapping. In the body of the matrix are specific elements which are empirically associated with the construct and are grouped under the appropriate unit of analysis. These paradigms may be relevant for more than one unit of analysis and rather than list them in separate columns, they are included under the Paradigms heading. The matrix also has a separate column to specify well-validated paradigms used in studying each Construct. The matrix columns specify Units of Analysis used to study the Constructs, and include genes, molecules, cells, circuits, physiology, behavior, and self-reports. In its present form, there are five Domains in the RDoC matrix: Negative Valence Systems, Positive Valence Systems, Cognitive Systems, Systems for Social Processes, and Arousal/Regulatory Systems. Constructs are in turn grouped into higher-level Domains of functioning, reflecting contemporary knowledge about major systems of cognition, motivation, and social behavior. The current RDoC framework consists of a matrix in which the rows represent specified functional Constructs, concepts summarizing data about a specified functional dimension of behavior, characterized in aggregate by the genes, molecules, circuits, etc., which implement it. Initially, a series of collaborative workshops was held in order to summarize the state of the knowledge related to five main “domains” and define associated constructs for each (see Appendix A). Since its inception, RDoC has progressed as a significant effort for the Institute, impacting basic, translational, and services/intervention research priorities. NIMH envisions that the RDoC initiative will determine how a classification approach based on biology, behavior, and context can be useful for mental disorders, thus informing diagnostic systems of the future. ![]() RDoC is a research framework designed to integrate many levels of information (from genomics to self-report) to better understand the basic dimensions of functioning underlying the full range of human behavior, from normal to abnormal. The National Institute of Mental Health (NIMH) launched the Research Domain Criteria (RDoC) in 2009 in response to the 2008 NIMH Strategic Plan’s call for new ways of classifying mental illnesses that are based on dimensions of observable behavioral and neurobiological measures. SECTION I: EXECUTIVE SUMMARY Introduction ![]() Appendix A: RDoC Matrix Domain, Constructs and Subconstruct Definitions.AROUSAL AND REGULATORY SYSTEMS FINAL REPORT.SYSTEMS FOR SOCIAL PROCESSES FINAL REPORT.SUMMARY OF RECOMMENDATIONS AND CONCLUSIONS.THE WORKGROUP ON TASKS AND MEASURES FOR RDOC.Research Training and Career Development Opportunitiesīehavioral Assessment Methods for RDoC Constructs August 2016 A Report by the National Advisory Mental Health Council Workgroup on Tasks and Measures for Research Domain Criteria (RDoC) TABLE OF CONTENTS.Research Conducted at NIMH (Intramural Research Program).Upcoming Observances and Related Events.Contribute to Mental Health Research Mobile navigation ![]()
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